What’s the Difference Between Methamphetamine and Amphetamines? Addiction, BlogBy Clarity WayJune 27, 2016When it comes to amphetamine vs. methamphetamine, there are not too many differences. In terms of chemistry, these two drugs are very similar. Both are controlled substances. Both can be abused and both are addictive. And while both of these drugs can have serious consequences when abused, one is much worse than the other.